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Fixed an issue with deleting recent history not working properly.Fixed an issue with the display of truncated GIF images.Fixed several issues with animated WebP display (animations stopping, corrupted frames on lossy images, etc.).Fixed a crash occurring when using HTTP pipelining over some (broken) proxies.Fixed issues with copying/pasting bookmarks in the Library View.Changed the about:feeds icon for external applications to a generic icon, since that kind of access to executables is no longer allowed for security reasons.The latest version available is Pale Moon 28.2.2, which has been recently released, bringing the below changes: Pale moon is based on Firefox, has support for the official Firefox extensions, but does not contain all of the Firefox features, including: social API, accessibility features, WebRTC and has some specific customizations and configuration options which are not available on Firefox.Īlso worth mentioning, Pale Moon did not adopt the Australis interface and is not planning to. The packages for Linux can be downloaded from here: Īs you may know, Pale Moon is an open-source, cross-platform browser based on Mozilla Firefox, being up to 25% faster then the original. I prefer to use gdebi due to the fact that it also handles dependencies, but the software is not installed by default on Linux systems. All you need to do is download the package and install it via your default package manager. DNA-74068 Switching news off and back on does not render contentĭue to the fact that it is available as a deb package, Opera can be easily installed on Ubuntu, Linux Mint and Elementary OS.DNA-73054 Crash on exit when add to bookmarks popup opened and window closed.DNA-73639 Pinned tab can be closed by Cmd+W.91, which has been recently released, bringing the below changes: First, it has been built on the Blink layout engine, but after a while, it has adopted the Chromium browser engine.Īmong others, it includes private browsing, tabbed browsing, a download manager and can integrate easily with social services, like WhatsApp and Facebook. The browser is available for Windows, Mac OS X and Linux and has been developed by Opera Software AS. $ sudo add-apt-repository ppa:kazam-team/stable-seriesĪs you may know, Opera is a popular, open-source, cross-platform internet browser. The latest stable version available is Kazam 1.4.5, which has been released a while ago.ĭue to the fact that it is available via the default repositories of Ubuntu 18.10 Cosmic Cuttlefish, Ubuntu 18.04 Bionic Beaver, Linux Mint, Elementary OS and other Ubuntu derivative systems, all you need to do is update the local repository index and install the kazam package:įor Ubuntu 14.04 Trusty Tahr, Linux Mint 17.x and Elementary OS 0.3 Freya, we need to use a third party PPA in order to install the software, refresh the repo list and install the kazam package from the newly added ppa: You can record your endire desktop or a portion of it.Īmong others, it has support for mp4 (H264), web (VP8) and avi formats, it allows the users to customize the framerate, has an option to show or hide the mouse cursor when recording, automatic file saving and adjustable keyboard shortcuts. This tool is very useful if you want to make video tutorials on Ubuntu. To launch, use "ubuntu1804" on the command-line prompt or Windows Terminal, or click on the Ubuntu 18.04.6 LTS tile in the Start Menu.įor more information about Ubuntu WSL and how Canonical supports developers please visit:As you may know, Kazam is an open-source application for creating screen recordings and screen shots of your Linux Desktop. Search for "Turn Windows features on or off" in the Windows search bar and ensure that "Windows Subsystem for Linux" is turned on before restarting your machine. Upgrades to future LTS releases will not be proposed. Ubuntu 18.04.6 LTS is the LTS version of Ubuntu and receives updates for five years. 5 years of security patching with Ubuntu Long Term Support (LTS) releases A consistent development to deployment workflow when using Ubuntu in the cloud Leverage GPU acceleration for AI/ML workloads with NVIDIA CUDA Manage Docker containers with improved performance and startup times Efficient command line utilities including bash, ssh, git, apt, npm, pip and many more Develop cross-platform applications, improve your data science or web development workflows and manage IT infrastructure without leaving Windows. Install a complete Ubuntu terminal environment in minutes with Windows Subsystem for Linux (WSL). From the Kingdom of Khotan, on the southern leg of the Silk Road, yearly tribute payments consisting of the most precious white jade were made to the Chinese Imperial court and there worked into objets d'art by skilled artisans as jade had a status-value exceeding that of gold or silver. The river jade collection is concentrated in the Yarkand, the White Jade ( Yurungkash) and Black Jade ( Karakash) Rivers. There, white and greenish nephrite jade is found in small quarries and as pebbles and boulders in the rivers flowing from the Kuen-Lun mountain range eastward into the Takla-Makan desert area. From the earliest Chinese dynasties to the present, the jade deposits most used were not only those of Khotan in the Western Chinese province of Xinjiang but other parts of China as well, such as Lantian, Shaanxi. Jade was considered to be the "imperial gem" and was used to create many utilitarian and ceremonial objects, from indoor decorative items to jade burial suits. In the Yin Ruins of the Shang Dynasty (1600 to 1050 BC) in Anyang, Dushan Jade ornaments were unearthed in the tomb of the Shang kings. Dushan Jade (imitation jade) was being mined as early as 6000 BC. Main article: Chinese jade Jade pendant in the shape of a dragon, Western Han Dynasty (202 BC – 9 AD)ĭuring Neolithic times, the key known sources of nephrite jade in China for utilitarian and ceremonial jade items were the now-depleted deposits in the Ningshao area in the Yangtze River Delta ( Liangzhu culture 3400–2250 BC) and in an area of the Liaoning province and Inner Mongolia ( Hongshan culture 4700–2200 BC). History East Asia Prehistoric and historic China Nephrite is derived from lapis nephriticus, a Latin translation of the Spanish piedra de ijada. The English word jade is derived (via French l'ejade and Latin ilia 'flanks, kidney area') from the Spanish term piedra de ijada (first recorded in 1565) or 'loin stone', from its reputed efficacy in curing ailments of the loins and kidneys. The use of jade in Mesoamerica for symbolic and ideological ritual was influenced by its rarity and value among pre-Columbian Mesoamerican cultures, such as the Olmecs, the Maya, and other ancient civilizations of the Valley of Mexico. It is commonly used in Latin America, such as Mexico and Guatemala. Jade is well known for its ornamental use in East Asian, South Asian, and Southeast Asian art. Jade can refer to either of two different silicate minerals: nephrite (a silicate of calcium and magnesium in the amphibole group of minerals), or jadeite (a silicate of sodium and aluminum in the pyroxene group of minerals). It is typically green, although may be yellow or white. Jade is a gemstone used as jewelry or for ornaments. 11,999.Intergrown grainy or fine fibrous aggregate Sensors on the phone include accelerometer, ambient light sensor, compass/ magnetometer, proximity sensor, and fingerprint sensor.Īs of 29th November 2023, Redmi 12 5G price in India starts at Rs. It features an IP53 rating for dust and water protection.Ĭonnectivity options on the Redmi 12 5G include Wi-Fi 802.11 a/b/g/n/ac, GPS, Bluetooth v5.00, NFC, and USB Type-C with active 4G on both SIM cards. It was launched in Jade Black, Moonstone Silver, and Pastel Blue colours. The Redmi 12 5G measures 168.60 x 76.28 x 8.17mm (height x width x thickness) and weighs 199.00 grams. The Redmi 12 5G runs MIUI 14 is based on Android 13 and packs 128GB, 256GB of inbuilt storage that can be expanded via microSD card (up to 1000GB) with a dedicated slot. It has a single front camera setup for selfies, featuring an 8-megapixel sensor. The Redmi 12 5G supports proprietary fast charging.Īs far as the cameras are concerned, the Redmi 12 5G on the rear packs a dual camera setup featuring a 50-megapixel primary camera, and a 2-megapixel camera. The Redmi 12 5G runs Android 13 and is powered by a 5000mAh non-removable battery. Redmi 12 5G is powered by an octa-core Qualcomm Snapdragon 4 Gen 2 processor. The display sports Gorilla Glass for protection. The phone comes with a 90 Hz refresh rate 6.79-inch touchscreen display offering a resolution of 2460x1080 pixels (FHD+). Redmi 12 5G mobile was launched on 1st August 2023. When he urges people to invest for their retirements but stands ready to invest their pensions into companies destroying their future, Fink has his self interest in mind, not the long term interest of his clients. “Larry Fink says that he encourages people to invest with a long term perspective, but he insists that they must have a choice of investing in the fossil fuel polluters that pose a long-term risk. Lucie Pinson – Executive Director, Reclaim Finance: BlackRock is leaning into offering clients choice, but deference to choice can’t be a shield for abdication of responsible risk management.” Fiduciary duty is about prioritizing clients’ best interests, which requires responsible and proactive management of risk. “Climate change is the single biggest long-term threat to financial markets, with impacts already felt across the economy. Jessye Waxman – Senior Campaign Representative, Sierra Club: Continuing to steer client investments into the very causes of the climate crisis is engineering an outcome - further climate chaos and the financial crises that will ensue.” This ignores the fact that maintaining the status quo is as much a choice as taking action. However, Fink claims that BlackRock shouldn’t engineer outcomes related to climate change. “Fink has again recognized, as any clear-eyed observer would, that climate change risk is having a material impact in the world, citing rising insurance costs due to climate change numbers. Moira Birss – Climate Finance Director, Amazon Watch: Partners within the BlackRock’s Big Problem network, a coalition of environmental, investor, and grassroots advocacy organizations, issued the following statements: Today, BlackRock released CEO Larry Fink’s annual chairman letter, for the first time addressing shareholders, clients, CEOs, investee companies, and other stakeholders in one statement. I wanted clothes that expressed my style, but I wanted them functional too. Where was I going to wear all those cocktail dresses and pantsuits? I’ve survived a hell of a year, why am I going to punish myself with control garments and heels? And the other half… it no longer made sense. I realized I didn’t need half of what I owned. Surviving a pandemic, at least for me, changed how I look at my wardrobe. I was not a golfer (though since writing this I have taken golf lessons), I didn’t play tennis or pickleball, and even if I had a kid I didn’t want to LOOK like a mom. After that, skorts again became the attire of moms or those on the courts or links. That time in college was the last time I wore a skort and I swore the last time I ever would. In college in the '90s, I had a black skort: from the front, it looked like a mini a-line skirt but the back showed it was divided, offering coverage and comfort. Growing up in the '70s and '80s, my mom and the moms of my friends wore culottes, which had elasticized waists and sharp pleats pastel polyester or crisp cotton twill hitting the knee, paired with pastel striped polo shirts and tees. The Best Skorts for Grown Women My History with Skorts This post has been updated several times since its original publish date in 2021 as I have tried new skorts and learned more about brands. But maybe after this past year, you're considering skorts again and are wondering what are the best skorts for grown women and women over 40. Practical, comfortable, but if you’re like me you may have decided you’d never have one in your closet. If you want to give your study of calculus a solid foundation, you should read these explanations. With this in mind, I’ve put a lot of effort into explaining the underlying logic of many of the ideas in this book. It can be a great aid to true understanding of calculus - or any math topic for that matter - to focus on the why in addition to the how-to. In the step-by-step problem-solving methods, the general action you need to take is in bold, followed by the specifics of the particular problem. The following conventions keep the text consistent and oh-so-easy to follow:Ĭalculus terms are italicized and defined when they first appear in the text. All explanations are in plain English, not math-speak. Only later do I give you the fancy calculus formulas. I then show you how the calculus concepts work in concrete examples. Whenever possible, I explain the calculus concepts by showing you connections between the calculus ideas and easier ideas from algebra and geometry. Calculus For Dummies, 2nd Edition, takes calculus out of the ivory tower and brings it down to earth. Non-student readers will find the book’s exposition clear and accessible. If you’ve had elementary calculus, but it’s been a couple of years and you want to review the concepts to prepare for, say, some graduate program, Calculus For Dummies, 2nd Edition will give you a thorough, no-nonsense refresher course. It covers the most important topics in the first year of calculus: differentiation, integration, and infinite series. If you’re enrolled in a calculus course and you find your textbook less than crystal clear, this is the book for you. About This BookĬalculus For Dummies, 2nd Edition, is intended for three groups of readers: students taking their first calculus course, students who need to brush up on their calculus to prepare for other studies, and adults of all ages who’d like a good introduction to the subject. Read this jargon-free book, get a handle on calculus, and join the happy few who can proudly say, Calculus? Oh, sure, I know calculus. There are many who say that calculus is one of the crowning achievements in all of intellectual history. Everest? Why listen to Beethoven’s Ninth Symphony? Why visit the Louvre to see the Mona Lisa? Why watch South Park? Like these endeavors, doing calculus can be its own reward. If you can do algebra, geometry, and trig, you can do calculus.īut why should you bother - apart from being required to take a course? Why climb Mt. It builds upon and is a logical extension of those subjects. Much of calculus is really just very advanced algebra, geometry, and trig. It’s not nearly as tough as its mystique would lead you to think. Well, I’m here to tell you that you can master calculus. Others who have no intention of ever studying the subject have this notion that calculus is impossibly difficult unless you happen to be a direct descendant of Einstein. The mere thought of having to take a required calculus course is enough to make legions of students break out in a cold sweat. Calculus For Dummies, 2nd Edition provides a roadmap for success, and the backup you need to get there. With this comprehensive study guide, you'll gain the skills and confidence that make all the difference. Stop fearing calculus, and learn to embrace the challenge. Features things to remember, things to forget, and things you can't get away with.Instructs you how to approximate area with integration.Explores sequences, series, and graphing common functions.Includes foundations in algebra, trigonometry, and pre-calculus concepts.It's the logical extension of the algebra, geometry, and trigonometry you've already taken, and Calculus For Dummies, 2nd Edition proves that if you can master those classes, you can tackle calculus and win. Breaking that barrier down means recognizing calculus for what it is-simply a tool for studying the ways in which variables interact. Through relevant instruction and practical examples, you'll soon learn that real-life calculus isn't nearly the monster it's made out to be.Ĭalculus is a required course for many college majors, and for students without a strong math foundation, it can be a real barrier to graduation. This user-friendly math book leads you step-by-step through each concept, operation, and solution, explaining the "how" and "why" in plain English instead of math-speak. By breaking down differentiation and integration into digestible concepts, this guide helps you build a stronger foundation with a solid understanding of the big ideas at work. Slay the calculus monster with this user-friendly guideĬalculus For Dummies, 2nd Edition makes calculus manageable-even if you're one of the many students who sweat at the thought of it. You can follow the guide in this post to easily download and install Yandex Browser for Windows 11/10/8/7 or Mac computer, Android phone or tablet, or iPhone/iPad. Tap the Installed tab and tap Yandex Browser > Uninstall to remove this browser from your Android device. To uninstall Yandex Browser on Android, you can open Google Play, tap the three-line icon and select My apps & games. If you want to set Yandex as the default browser on Android, you can open the browser and open a new tab, tap the three-dot icon and tap Default Browser. Tap Yandex Brower with Alice and tap Update to install the latest version of the Yandex Browser app. To update Yandex Browser on an Android mobile device, you can open Google Play, tap the three-line icon in the upper-left corner and tap My apps & games. Install, Update, Uninstall Yandex Browser on Androidįor Android phones and tablets, you can easily find Yandex Browser from Google Play Store and simply tap Install to download and install Yandex Browser for your Android mobile devices.įor Huawei mobile devices, you can open Huawei AppGallery to search for Yandex Browser to download it. Alternatively, you can also go to and click Download to download Yandex Browser for Mac.įor iPhone or iPad, you can open App Store on your device to search for Yandex Browser to download and install this browser with one click. Yandex Browser is also available for Mac, iPhone, and iPad.įor a Mac, you can open Mac App Store on your computer to search for Yandex Browser. How to Download Yandex Browser for Mac/iPhone/iPad Next time you can quickly launch Yandex Browser from Windows taskbar bar. To pin Yandex Browser to the taskbar, you can click press Windows + S, type yandex, right-click Yandex App, and select Pin to taskbar. How to Pin Yandex Browser to the Taskbar on Windows After this, any links you click on will automatically open in this browser. Click “Yes, do it” under “Make Yandex your default browser”. If you don’t see the pop-up window, you can click the three-line icon at the top-right corner and select Settings. If you want to set Yandex as the default browser, you can open Yandex Browser, and click “Yes, please” in the pop-up “Make Yandex your default browser” window. How to Make Yandex Browser Your Default Browser To open Yandex Browser next time, you can double-click the Yandex shortcut icon on your desktop. Select a search engine for Yandex Browser: Yandex, Baidu, or 360. Click Install to fast install Yandex Browser on your Windows 11/10/8/7 computer. Decide if you want to check the “Set as default browser” and the “Pin Alice to the taskbar” options. You can also open the folder that contains the downloaded Yandex Browser setup file to easily launch its installer. After it finishes downloading, you can click the Yandex.exe icon at the bottom-left to launch the installer. You can go to in your browser and click the Download button to start downloading the Yandex Browser. You can easily download Yandex Browser 64-bit or 32-bit version for your Windows 10/11 PC. How to Download and Install Yandex for Windows 11/10/8/7 System Requirements to Download Yandex Browser If you want to install the Yandex Browser app on your device, you can check how to download Yandex Browser for Windows 10/11, Mac, or mobile devices below. You can also access and use Yandex Search by going to in other browsers like Google Chrome. Yandex Browser is available for Windows, macOS, Linux, Android, and iOS. This browser is the second most popular desktop web browser in Russia. Yandex Browser is a free web browser developed by the Russian company Yandex. Install, Update, Uninstall Yandex Browser on Android.How to Download Yandex Browser for Mac/iPhone/iPad.How to Download and Install Yandex for Windows 11/10/8/7. System Requirements to Download Yandex Browser.For more useful computer tools, you may visit MiniTool Software official website. This post introduces how to download Yandex Browser for PC, Mac, Android, or iPhone/iPad. I only bought an external speaker when I wanted to hear even better sound quality. When I was using a Windows PC, I always needed to have good-quality external speakers.īut when I shifted to Mac, I didn’t bother to buy external speakers for a long time. Height: 88.One thing I liked when I first shifted from Windows PC to Mac is the big difference when it comes to the sound quality of their built-in speakers.Internal power supply with toroidal transformer.EQ switchable before and after the compressor.If you’ve never heard it, it’s that EQ that you’ve always been looking for. Hear it only once, and you’ll forever miss its absence. The result is an EQ you really have to hear. This gives the Crème its accurate stereo tracking features. Limiting the range of settings possible to reasonably required values has made these adjustments much more precise. Similarly, unnecessary frequencies have been removed from the mix bus.Īll controls have been replaced with rotary switches for greater precision. Unnecessary controls have been replaced by fixed values. Tegeler took the filter circuitry from the original Pultec and carefully updated it. A bass boost that gives the mix a solid foundation and thrust, without squashing everything into an indistinct nothingness. Soft and silky highs that deserve the name. The Creme features the filter circuitry from the original Pultec for good reason - no other type of EQ manages to sound as good in almost any matter of setting. Passive equalizers with their elaborate circuits with coils and capacitors are still among the most popular sound makers in master compression. Frequency response: 20 - 40 kHz ☑.5 dB.The switchable high-pass filter in the side chain ensures that, when required, even heavy bass sounds don’t lead to pumping. The often lamentable loss of high notes in compression simply doesn’t happen here – rather, the signal sounds like it has already been fed through an exciter.īass sounds like a unified whole and refined with lean dynamics. The compression is very harmonic in nature, the sound always remains transparent, and the individual instruments find their own place in the mix. The compressor can really work hard, giving your mix a more noticeable open and brilliant sound. Its characteristic and powerful sound can bring every mix to the next level. THE COMPRESSORĭo you want to softly and inaudibly balance the track or give it a particular rhythmic signature? The Crème’s VCA compressor can do all this. Similarly, the Crème is suitable for use in mastering as well. The placement of the EQ and compressor in the mix can also be switched. The bus compressor has a few additional functions such as a low-pass filter for the side chain and an additional ratio of 1.5:1 for especially subtle compression. The boost has been made switchable to enable total recall and to reduce the boost to more appropriate levels for use on the master channel. The passive EQ has been reduced down to the most popular applications: Bass boost, to give greater definition to the bass, and treble boost, to give the mix the necessary shine. The Tegeler Audio Creme Bus Compressor and Mastering Equalizer puts the very best of both functions into one device. It also helps in finding the right volume balance for individual sounds (especially vocals). This gives the engineer an idea of how the mix will sound after mastering, even still during in the mixing stage. The EQ is usually set to subtly boost the bass and treble, while the bus compressor compresses the sound by a couple of dB. Many successful mixing engineers share one thing in common: They mix with a compressor and EQ in the master channel. Tegeler Audio Creme Bus Compressor and Mastering Equalizer Big Bear Gift shop, over 8,000 sq feet of treasures and also housing Arizona’s largest model train, a historically accurate replica of the railroad from Williams depot to the grand canyon. All Shows which include animal meet-n-greets and training presentations. The Raptor Free Flight program, where birds of prey fly right over your head. The barnyard, which is our petting zoo and fun for all ages. This is where you will find our smaller animals like river otters and bobcats. Where the drive thru ends Fort Bearizona begins. In these free roaming areas You will see wolves, bears, bison, and many other large species that can come right up to your car. In the drive thru, you will take your own vehicle or our Wild Ride Bus through pristine Natural habitats for many North American Species. The park consists of a 3 mile drive thru and Fort Bearizona. We are right off Route 66 on the way to the Grand Canyon, just a short drive from Sedona and Flagstaff. We are a Wildlife adventure, open year round.Located on 160 acres in the city of Williams Az. Over 20 miles of trails offer opportunities for everybody to have a winter adventure! In the winter season, the Arizona Nordic Village hosts a groomed trail system for cross country skiing, snowshoeing, and fatbiking. Many miles of hiking and biking trails leave right from the Village, and there are numerous other activities nearby, including the Lava River Cave, Red Mountain, Arizona Snowbowl, the Arizona National Scenic Trail, and many other hiking and biking trails. Frontcountry yurts and cabins are available for those seeking easy access, and five backcountry yurts offer solitude and natural settings with more comforts than a typical backpacking adventure. Perfectly situated in the cool pine and aspen forests at 8,000 ft of elevation between Flagstaff and Grand Canyon National Park, the Village offers rustic cabin and yurt rentals year-round, and summer campsites that are RV-friendly. Stay in a yurt or cabin at the AZ Nordic Village, a premier outdoor recreation destination just north of Flagstaff. Please take great caution when driving this stretch of the highway in inclement weather. That's where the majority of vehicle accidents take place. Second, I-40 gets extremely slick during winter storm conditions in the stretch of highway between Flagstaff and Ashfork. I-40 has a couple not so great features that are good to know about. Make sure to check road conditions and traffic reports prior to embarking on your journey. There is often bumper-to-bumper traffic when there is an accident or construction on this highway, which unfortunately happens pretty often - especially in inclement weather. I-40 is the main East/West artery that goes through Flagstaff. I-40 Traffic Warnings and Road Conditions If you plan on going to Arizona Snowbowl Ski Resort, they will require 4WD, AWD or chains to go up to the ski resort when it is snowing or if Snowbowl Rd. 4WD, AWD and chains are useful to have if you plan on driving during a storm. Munds Park tends to get icy and slick, so definitely slow down on this stretch of your drive. If there has been a recent snowstorm, this is where you should start taking caution. But winter road conditions don't usually get real until you pass the Stoneman Lake Road exit on the I-17. Sedona also gets some snow every now and then, which just makes for a stunning view. You usually won't have to worry about winter road conditions this soon in your drive, but always check for winter storm and weather conditions before heading north. Snow can be seen as far south as Prescott, but typically it falls in the higher elevations of the mountains. Winter Conditions It's hard to believe, but yes, Arizona gets snow and Flagstaff can get a lot of it. That's your best window, otherwise, traffic is often bumper to bumper and can add 1-3 hours to your time on the road. We recommend that you travel north on a Friday night after 7pm or before 9am on Saturday. You can count on traffic starting on the I-17 as far south as Black Canyon City if you leave on a Saturday after 9am on a 3-day weekend. There is potential for slow-moving traffic on the way from Phoenix to Flagstaff during the weekend nearly year-round. » See Real Time Traffic & Road Conditions (ADOT) » See Current Weather Warnings & Forecast (NWS)ġ-17 Traffic Warnings and Road Conditions But you can use the Arizona Department of Transportation website to get more details regarding road closures, construction and weather conditions. Use your everyday apps like Google Maps and Waze to get a good idea of your travel time. Both of these highways can have regular traffic and road condition issues year-round. There are two main highways that go Flagstaff: I-17 from Phoenix and the I-40, which is most often taken from Las Vegas. CHAP randomized 2,404 pregnant women to BP targets recommended for nonpregnant reproductive-age adults ( 37 ☌ core temperature) after induction of mild hypothermia versus warming to “usual” levels ( ~ 35.5 ☌ core temperature), looking at which might be better for reducing myocardial injury.ĬLASP-TR, LBCT IV, Monday morning. Advice is mixed as to whether low-dose antihypertensives help or harm in pregnancy. The second aim of the trial, testing a hypotension-avoidance strategy versus a hypertension-avoidance strategy, will be presented during the fourth late-breaking session.ĬHAP, LBCT I. In the first late-breaking session, investigators will present the results of the randomization to tranexamic acid (TA) versus placebo to reduce bleeding, hoping to demonstrate superiority of TA for reducing bleeding and noninferiority for thrombotic events. The 10,000-patient POISE-3 trial in patients undergoing noncardiac surgery makes two appearances in this year’s program, thanks in part to its partial factorial design. POISE-3, LBCT I, Saturday morning, and LBCT IV, Monday morning. SODIUM-HF is randomizing 1,000 patients to either limit dietary sodium on their own, or to adhere to a stricter regimen of 1,500 mg/day or lower, to see whether the latter leads to fewer hospital readmissions or emergency department visits, or better survival. Patients with chronic HF are advised to restrict their sodium intake, typically to levels lower than 2,300-2,500 mg per day, said Drachman, but those recommendations are based on limited evidence. Following the “enormous improvements” seen with first-in-class cardiac myosin inhibitor mavacamten (Bristol Myers Squibb), in EXPLORER-HCM, VALOR-HCM is testing the agent against placebo in 100 people with symptomatic obstructive hypertrophic cardiomyopathy, with the aim of reducing the number of septal reduction therapy procedures. Restricted by time, Drachman selected what he termed a “top 10” list of trials that meet this bar, depending on how they ultimately pan out. Highlighting some of these trials during the media briefing, ACC Program Vice Chair Douglas Drachman, MD (Massachusetts General Hospital, Boston), observed that the ones that “really promise to be practice-changing science” cover the full spectrum of issues on the radar of cardiologists. This year’s 3-day meeting showcases 39 late-breaking clinical trials (LBCTs), spread over five sessions, as well as 15 featured clinical research presentations, held over three different sessions-all chosen from a total of 117 submissions, 56% of which came from outside the US. Over 300 sessions will be offered on demand, after the fact. Those watching remotely will need to navigate the six virtual channels to tune in live, with approximately 80 livestreamed sessions to choose from. An additional 944 faculty had accepted remote or digital roles, reflecting the ACC’s commitment to both the health and safety of the live, in-person meeting, while retaining the diversity afforded by the pandemic, when remote faculty contributed “ international perspectives” without having to be on-site, said Morris.įor those attending in person, ACC will have the classroom- and lecture-theatre-feel of meetings gone by, said Morris, with nearly 300 live sessions. According to Morris, fully 2,500 faculty would be presenting science in person, of whom 419 were from outside the United States. Some 6,800 health professionals had registered to attend in person and nearly 3,200 had registered to attend virtually. “I think you’ll find this is everything you’ve come to expect from the college and its flagship meeting and in my opinion, even more.”Īs of late last week, the ACC had just under 13,000 registered attendees, although that number was “increasing hourly,” a spokesperson told TCTMD. “I’m most excited by the fact that we are back to live education, and back to live education in the city that is the home of our ACC Heart House,” she said. In a press briefing earlier this month to preview this year’s most exciting trials and sessions, ACC Program Chair Pamela Morris, MD (Medical University of South Carolina, Charleston), told reporters: “Welcome back and welcome home.” The ACC 2022 Scientific Session kicks off Saturday, April 2, in Washington, DC, with what organizers describe as a return to the live, in-person format, but with both virtual and on-demand components for those who won’t be there in the flesh. The American College of Cardiology (ACC)’s annual meeting was the first large cardiology conference to switch to virtual when COVID-19 first hit and is now poised to be the first of its scope to welcome attendees back to the main tent. |
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